Top 5 Similac Formulas: A Comprehensive Review Guide

Holding your newborn, you want only the best for their tiny tummy and growing body. Did you know that choosing the right infant formula is one of the first big decisions you make as a parent? It can feel overwhelming! Similac is a name you see everywhere, offering many different types of formula, from gentle options to those packed with extra brain-boosting nutrients.

It’s tough trying to figure out which Similac product truly fits your baby’s specific needs. Maybe your little one has tummy troubles, or perhaps you are just looking for the closest option to breast milk. Navigating the labels—like Advance, Organic, or Total Comfort—can leave you scratching your head and feeling unsure.

This post cuts through the confusion. We break down the key differences between the most popular Similac formulas. You will learn exactly what each type offers so you can choose with confidence, ensuring your baby gets perfect nutrition. Keep reading, and let’s find the ideal Similac match for your little star!

Top Similac Formula Recommendations

SaleBestseller No. 1
Similac Advance Infant Formula With Iron, Baby Formula Powder, 30.8-oz Value Can
  • GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a Reward
  • EASY TO DIGEST: Similac Advance is nutritionally complete and inspired by breast milk
  • SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk
  • NO PALM OLEIN OIL: Designed to support excellent calcium absorption
  • NO ARTIFICIAL GROWTH HORMONES: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Advance is also kosher and halal
Bestseller No. 3
Similac 360 Total Care Infant Formula, Has 5 HMO Prebiotics, Our Closest Prebiotic Blend to Breast Milk, Non-GMO, Baby Formula, Ready to Feed, 2-fl-oz Bottle, Pack of 48
  • CLOSER TO BREAST MILK THAN EVER BEFORE: Similac 360 Total Care, our biggest formula breakthrough, has an exclusive blend of 5 HMO prebiotics structurally identical to those in breast milk
  • 360 WHOLE-BABY SUPPORT: Nutrition designed for immune support, brain development, and digestive health
  • HELPS STRENGTHEN THE IMMUNE SYSTEM: Similac 360 Total Care is designed to help strengthen baby’s immune system
  • CONVENIENT & READY TO USE: Great for on-the-go and late-night feeding; no mixing required
  • TRUSTED BRAND: Similac is the #1 infant formula brand chosen by parents
SaleBestseller No. 6
Similac Advance Infant Formula, Stage 2, Powder, 30.8 Ounces (Pack of 4)
  • EASY TO DIGEST: Similac Advance is nutritionally complete and inspired by breast milk
  • SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk
  • NO PALM OLEIN OIL: Designed to support excellent calcium absorption
  • NO ARTIFICIAL GROWTH HORMONES: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Advance is also kosher and halal
  • SIMILAC IS THE #1 INFANT FORMULA BRAND FED IN HOSPITALS
Bestseller No. 7
Similac Sensitive Infant Formula, for Fussiness & Gas Due to Lactose Sensitivity, Baby Formula Powder, 29.8-oz Value Can
  • GET MORE REWARDS POINTS: Scan the MySimilac QR code on select products to earn points toward a Reward
  • DESIGNED FOR BABY’S FUSSINESS & GAS: Our sensitive formula for babies is specially designed for fussiness and gas due to lactose sensitivity
  • SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk
  • NO PALM OLEIN OIL: Designed to support excellent calcium absorption
  • NO ARTIFICIAL GROWTH HORMONES: Similac was the first leading infant formula brand with no artificial growth hormones
SaleBestseller No. 8
Similac 360 Total Care Infant Formula, Has 5 HMO Prebiotics, Our Closest Prebiotic Blend to Breast Milk, Non-GMO, Baby Formula, Ready to Feed, 8-fl-oz Bottle, Pack of 24
  • HAS OUR CLOSEST PREBIOTIC BLEND TO THAT IN BREAST MILK: Similac 360 Total Care, our biggest formula breakthrough, has an exclusive blend of 5 HMO prebiotics structurally identical to those in breast milk
  • 360 WHOLE-BABY SUPPORT: Nutrition designed to help support the immune system, brain development, and digestive health
  • DESIGNED TO HELP STRENGTHEN THE IMMUNE SYSTEM: Similac 360 Total Care is designed to help strengthen baby’s immune system
  • CONVENIENT FOR ON THE GO: Ready-to-feed baby formula that’s easy to pack and nipple-ready; it requires no mixing and it’s great for late-night feedings
  • SIMILAC IS THE #1 INFANT FORMULA BRAND FED IN HOSPITALS

The Ultimate Buying Guide for Similac Formula

Choosing the right formula for your baby is a big decision. Similac is a popular brand that many parents trust. This guide will help you understand what to look for so you pick the best Similac product for your little one.

Key Features to Look For

When you look at Similac cans, several things stand out. These features help you match the formula to your baby’s needs.

  • Age Appropriateness: Similac makes formulas for newborns (Stage 1), older infants (Stage 2), and toddlers (Stage 3). Always buy the stage your baby needs right now.
  • Nutrient Profile: Look for DHA and ARA. These are important fats that help brain and eye development. Most Similac formulas include them.
  • Protein Source: Most standard Similac uses cow’s milk protein. If your baby has tummy trouble, you might need options like Similac Soy or Similac Alimentum (for sensitivity).
  • Prebiotics/Probiotics: Some formulas include these “good” bacteria or fibers. They support healthy digestion, which is great for gassy babies.

Important Ingredients and Materials

Similac formulas are carefully made. The ingredients are chosen to mimic breast milk as closely as possible.

The Core Components

The main part of any Similac formula is usually lactose (a sugar found in milk) and a blend of proteins. You will also see vegetable oils that give your baby energy.

Specialized Additions

If you see “NeuroShine” on the label, this means it has extra lutein, iron, and DHA. Lutein is an antioxidant that protects the eyes. Iron is vital for blood health. These additions boost the nutritional value.

Factors That Improve or Reduce Quality

The “quality” of the formula often comes down to how well your baby tolerates it and how clean the ingredients are.

What Makes a Similac Formula High Quality?
  • Easy Digestion: If your baby digests the formula easily, without excessive spit-up or gas, that formula is working well for them.
  • Consistency: Similac is known for consistent mixing. Good quality means the powder dissolves smoothly in water.
  • Organic Options: Similac Organic is made without artificial growth hormones or antibiotics. Many parents feel this is a higher quality choice for their baby’s diet.
When Might Quality Seem Lower?

If a baby shows signs of allergy or intolerance—like severe rash or constant fussiness after switching—that specific formula is not the right quality *for that baby*. Sometimes, the issue is not the formula itself, but simply that your baby is sensitive to milk protein.

User Experience and Use Cases

Parents choose Similac for different reasons, leading to various user experiences.

Common Use Cases
  • General Growth: Most healthy babies thrive on Similac Advance or Similac Organic. Parents report babies gain weight well and seem satisfied after feeding.
  • Premature or Low Birth Weight Babies: Similac makes specialized formulas (like Similac NeoSure) designed for babies born early. Doctors recommend these to help catch up on growth quickly.
  • Tummy Troubles: If standard formula causes problems, parents often switch to Similac Sensitive (which has less lactose) or Similac Total Comfort. These specialized lines usually lead to quieter stomachs and happier babies.

The feeding experience is usually straightforward. Parents appreciate that Similac products are widely available in stores. If you use the Similac Ready-to-Feed bottles, mixing time is eliminated, which is a huge time-saver for tired parents!


10 Frequently Asked Questions (FAQ) About Similac Formula

Q: Is Similac better than Enfamil?

A: Neither brand is universally “better.” Both are excellent and meet FDA standards. The best one depends on your baby’s specific digestive needs and what your pediatrician recommends.

Q: Can I mix Similac with breast milk?

A: Yes, you can mix Similac powder with expressed breast milk. However, do not add powder to already warmed breast milk. Always mix powder with water first, or mix it directly into the bottle with the milk.

Q: What is the difference between Similac Advance and Similac Organic?

A: Similac Advance is the standard, widely available formula. Similac Organic is made with ingredients grown without synthetic pesticides or fertilizers.

Q: How long can mixed Similac formula stay in the fridge?

A: Once prepared, liquid Similac formula can safely be stored in the refrigerator (covered) for up to 48 hours.

Q: My baby spits up a lot. Should I switch to Similac Sensitive?

A: Talk to your doctor first. Similac Sensitive has partially broken-down proteins, which can help babies with fussiness or gas. It is not specifically for reflux, but it often helps mild tummy issues.

Q: Do I need to boil the water when mixing Similac powder?

A: Yes, the CDC recommends using water that has been boiled for one minute and then cooled, especially for babies under three months old.

Q: What does DHA in Similac help with?

A: DHA is an omega-3 fatty acid. It is very important for building a baby’s brain and eyes during the first year of life.

Q: Is Similac Soy a good choice for all babies?

A: No. Similac Soy is only recommended if a doctor confirms your baby has a true lactose intolerance or a specific soy-based allergy. It is not the first choice for cow’s milk allergies.

Q: Why is Similac sometimes more expensive?

A: Formulas with added specialty ingredients, like organic certification or added prebiotics, often cost more due to ingredient sourcing and processing.

Q: How often should I switch Similac types if my baby seems fussy?

A: Do not switch formulas quickly. Give any new formula at least 7 to 10 days to see if your baby adjusts. Rapid switching can cause more digestive upset.