Top 5 Heartworm Pills: Dog Owner’s Quick Guide

Did you know a tiny mosquito bite can carry a deadly threat to your furry best friend? Heartworm disease, spread by mosquitoes, is a serious and often fatal condition for dogs. Preventing it is much easier—and cheaper—than treating it later. But when you walk into the pet store or look online, the sheer number of heartworm pills available can feel overwhelming. Which one is best for your dog’s needs? How do you know you are choosing the right protection?

Many dog owners worry about side effects, cost, and finding a reliable monthly treatment schedule. It’s tough to sort through all the brand names and figure out what truly works for your lifestyle and your pup’s health profile. You want peace of mind knowing your dog is safe from this sneaky parasite.

This guide cuts through the confusion. We will break down the most popular heartworm preventatives, explain how they work, and help you understand the key differences between them. By the end of this post, you will feel confident choosing the perfect heartworm pill to keep your dog happy and healthy all year long. Let’s dive into the essential facts about protecting your dog from heartworms.

Top Heartworm Pills For Dogs Recommendations

SaleBestseller No. 1
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover, Puppy Dewormer (Praziquantel & Pyrantel Pamoate), 2 Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable large dog dewormer treats and controls 7 species of worms: 2 tapeworms, 2 roundworms, and 3 types of hookworms
  • Vet Quality Deworming for Dogs: These vet-quality tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
  • Dewormer Tablets: PetArmor broad spectrum canine dewormer comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dewormer for puppies is not rejected and the full dose of dewormer is eaten
  • Recommended Use: For best results with PetArmor dog dewormer, read and follow label instructions; if you need to retreat your dog, we recommend consulting with a veterinarian and have them perform a fecal test to rule out other issues or parasites
Bestseller No. 2
HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51-100 lbs (Brown Box) 6 Month Supply of Chews (Heartworm Disease Preventive)
  • Vet-recommended heartworm preventive
  • Effectively prevents heartworm disease
  • Also treats and controls roundworms & hookworms
  • From the brand trusted over 2.5 billion times⁵
  • Delicious once a month real-beef chew that dogs love⁶
Bestseller No. 3
HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 6 Month Supply of Chews (Heartworm Disease Preventive)
  • Vet-recommended heartworm preventive
  • Effectively prevents heartworm disease
  • Also treats and controls roundworms & hookworms
  • From the brand trusted over 2.5 billion times
  • Delicious once a month real-beef chew that dogs love
Bestseller No. 4
TRI-HEART PLUS Chewable Tablet for Dogs, up to 25 lbs (Blue Box), 6 Chewable Tablets, 6-Month Supply
  • Prevents heartworm disease, treats, and controls roundworms and hookworms
  • Kills heartworm larvae before they reach your dog’s heart
  • Enjoy year-round protection for your dog, with monthly treatments
  • Easy-to-give, beef-flavored, chewable tablet that your dog will enjoy.
  • Safe for dogs with beef allergies
Bestseller No. 5
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment of Tapeworm, Roundworm & Hookworm, Dewormer for Puppies & Small Dogs (6-25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable dewormer for small dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
  • Vet-Quality: These vet-quality puppy dewormer tablets are safe for puppies 12 weeks or older, and small dogs 6.0 to 25 lbs
  • Dewormer Tablets: PetArmor broad spectrum dewormer with pyrantel pamoate for dogs comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable 7 Way Dewormer for dogs is not rejected and the full dose of dewormer is eaten
  • Recommended Use: For best results with any PetArmor dog dewormer read and follow label instructions; if you need to retreat your dog, we recommend consulting with your veterinarian and performing a fecal test to rule out any other issues or parasites
Bestseller No. 6
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm, Small Dog Dewormer (6-25 lbs) with Praziquantel & Pyrantel Pamoate, 6 Flavored Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable dewormer for small dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
  • Vet Quality Dewormer for Puppies: These vet-quality tablets are safe for puppies 12 weeks or older, and small dogs 6.0 to 25 lbs
  • Dewormer Tablets: PetArmor broad spectrum tapeworm and hookworm dewormer for dogs comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewormer is not rejected and the full dose of dog tapeworm dewormer is eaten
  • Recommended Use: For best results with any PetArmor canine dewormer, read and follow label instructions; if you need to retreat your dog, consult with your veterinarian and have them perform a fecal test to rule out any other issues or parasites
Bestseller No. 7
Durvet Triple Wormer for Medium and Large Dogs
  • Convenient 12 Pack
  • Non prescription
  • Controls seven strains of tape; hook and roundworms
  • Chewable Tablets ; Packaging may vary
  • Feeding directions - 25.1 to 50.0 pounds, give 1 Medium/Large Dog(114mg) tablet . 50.1 to 100.0 pounds, give 2 Medium/Large Dog(114mg) tablets. 100.1 to 150.0 pounds, give 3 Medium/Large Dog(114mg) tablets. 150.1 to 200.0 pounds, give 4 Medium/Large Dog(114mg) tablets
Bestseller No. 8
Simparica Trio (sarolaner, moxidectin, and pyrantel chewable Tablets) Chewables for Dogs, 24 mg/tab, 22.1-44 lbs, (Blue), 1 Tablet
  • Don’t Just Protect, Triple Protect: Simparica Trio is a monthly chew that protects against three categories of parasites including heartworms, ticks & fleas, and intestinal worms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
  • Heartworm Protection: One dose provided 100% protection against heartworm disease in studies to support FDA-approval.
  • Kills 6 Types of Ticks & FDA-Approved to Prevent Lyme Infections*: The only combo preventative proven to kill six types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick, and Asian Longhorn Tick.
  • Kills Fleas & Intestinal Worms: Prevents flea infestations because it kills fleas before they lay eggs. Prevents tapeworms because it kills fleas. Treats and controls roundworms and hookworms.
  • Satisfaction Guaranteed: Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month, with or without food.

Your Guide to Choosing the Best Heartworm Pills for Your Dog

Heartworm disease is a serious threat to dogs. Tiny worms travel through your pet’s bloodstream, causing lung and heart damage. Protecting your dog with a monthly heartworm preventative is essential. This guide helps you choose the right medication.

Key Features to Look For

When buying heartworm pills, several important features matter.

  • Active Ingredients: Look for established, proven ingredients. The most common and effective ones are Ivermectin, Milbemycin Oxime, and Moxidectin. These ingredients kill the immature heartworms before they can grow up.
  • Broad-Spectrum Protection: The best pills often protect against more than just heartworms. Many also prevent intestinal worms like roundworms, hookworms, and whipworms. This gives you more bang for your buck.
  • Dosage Frequency: Most effective preventatives are given once a month. Some options are available as a six-month or annual injection, but monthly pills are easy for most owners to manage.
  • Weight Range: Pills come in different strengths based on your dog’s weight. Always choose the correct dosage for your dog’s current weight to ensure safety and effectiveness.
Important Materials (Ingredients)

The “material” in these pills is the medicine itself. The quality is determined by the established effectiveness of the drug used.

The primary materials are the active drug components mentioned above. Reputable manufacturers use high-quality sources for these drugs. Always check the label to confirm the exact drug and the milligram amount. Cheap, unverified products might use lower-quality materials or lack the correct dosage, putting your dog at risk.

Factors That Improve or Reduce Quality

What makes one heartworm pill better than another?

Quality Boosters:
  • Veterinary Approval: Medications approved by veterinary boards offer proven safety.
  • Added Parasite Control: Pills that include ingredients for flea and tick prevention automatically improve the overall quality of protection.
  • Taste/Palatability: Dogs are more likely to eat a tasty chewable tablet. Many modern pills are flavored (like beef or bacon) to make monthly dosing simple.
Quality Reducers:
  • Generic or Unknown Brands: If you have never heard of the brand, research it thoroughly. Low-quality generics might not work correctly.
  • Improper Storage: Medications must be stored correctly (usually at room temperature, away from moisture). Poor storage reduces the drug’s potency.
  • Incorrect Dosing: Giving too little medicine fails to kill the worms. Giving too much can cause side effects. Accuracy is key.
User Experience and Use Cases

How do these pills fit into your life? The user experience focuses on ease of use and your dog’s reaction.

For most owners, the ideal use case involves giving the pill easily during a regular routine, like dinner time. If your dog spits out the pill, the experience is frustrating. Therefore, chewable, flavored tablets are highly preferred by most users over hard-to-swallow tablets.

It is important to note that heartworm prevention must start early. Puppies can usually begin prevention around six to eight weeks of age. If you adopt an adult dog, the veterinarian must test the dog for existing heartworms before starting preventative medication. If the dog already has heartworms, treatment is much more complex than simple monthly pills.


Frequently Asked Questions (FAQ) About Heartworm Pills

Q: How often do I need to give the heartworm pill?

A: Most heartworm preventatives require you to give your dog one pill once every 30 days, or once a month.

Q: Can I skip a month if I forget?

A: You should try never to skip a dose. If you miss one dose, give the next pill as soon as you remember, and then resume the normal monthly schedule. Missing doses significantly increases the risk of infection.

Q: Do I need a prescription for heartworm pills?

A: Yes, in most countries, you need a current prescription from your veterinarian. This is because the vet must perform an annual heartworm test to ensure your dog does not already have worms before prescribing the preventative.

Q: Are heartworm pills safe for puppies?

A: Yes, many heartworm preventatives are safe for puppies starting at a very young age, often six to eight weeks old. Always confirm the appropriate starting age with your vet.

Q: What happens if my dog vomits after taking the pill?

A: If your dog vomits immediately (within 30 minutes) after taking the pill, the medication might not have been fully absorbed. Call your vet; they will likely advise you to give another dose.

Q: Are there any side effects to heartworm pills?

A: Most dogs tolerate these medications very well. Mild side effects, like slight lethargy or digestive upset, can sometimes occur, but severe reactions are rare.

Q: Can these pills prevent fleas and ticks too?

A: Some combination products do offer protection against fleas and ticks along with heartworms. Look for products that specifically list these other pests on the label.

Q: If my dog only goes outside occasionally, do I still need the pill?

A: Yes. Mosquitoes carry heartworm larvae, and they only need one bite to transmit the disease. Even indoor dogs are at risk, so prevention is necessary year-round.

Q: How long do I have to give my dog heartworm prevention?

A: Most veterinarians recommend year-round, 12-month prevention to keep your dog fully protected, even in cold climates where mosquitoes might disappear for a few months.

Q: Can humans get heartworms from dogs?

A: No. Heartworms are specific to the animal they infect. Humans cannot catch heartworms from dogs, and dogs cannot catch them from humans.